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Fine particulate air pollution and premature ventricular contractions: The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study.

TitleFine particulate air pollution and premature ventricular contractions: The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study.
Publication TypeJournal Article
Year of Publication2017
AuthorsO'Neal, WT, Soliman, EZ, Efird, JT, Howard, VJ, Howard, G, McClure, LA
JournalEnviron Res
Volume154
Pagination115-119
Date Published2017 04
ISSN1096-0953
KeywordsAfrican Americans, Aged, Cohort Studies, Environmental Exposure, Female, Humans, Male, Middle Aged, North Carolina, Particulate Matter, Risk Factors, United States, Ventricular Premature Complexes
Abstract

BACKGROUND: It is unknown if higher levels of ambient particulate matter (PM) exposure increase the risk for premature ventricular contractions (PVC) in a population-based study of men and women, and if this relationship varies by race or sex.METHODS: We examined the association of PM <2.5µm in diameter (PM) concentration with PVCs in 26,121 (mean age=64±9.3 years; 55% female; 41% black) participants from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. Estimates of short- (2-week) and long-term (1-year) PM exposures were computed prior to the baseline visit using geographic information system data on the individual level at the coordinates of study participants' residences. PVCs were identified from baseline electrocardiograms.RESULTS: PVCs were detected in 1719 (6.6%) study participants. Short- (OR=1.08, 95%CI=1.03, 1.14) and long- (OR=1.06, 95%CI=1.01, 1.12) term PM exposures were associated with PVCs. Interactions were not detected by race or sex. An interaction between short-term PM exposure and PVCs was detected for those with cardiovascular disease (OR=1.16, 95%CI=1.06, 1.27) compared with those without cardiovascular disease (OR=1.05, 95%CI=0.99, 1.12; p-interaction=0.027).CONCLUSION: Our findings suggest that PM exposure is associated with an increased risk for PVCs in a biracial population-based study of men and women. We also have identified persons with cardiovascular disease as an at-risk population for PVCs when increases in short-term PM concentration occur.

DOI10.1016/j.envres.2016.12.031
Alternate JournalEnviron. Res.
PubMed ID28061370
PubMed Central IDPMC5354125
Grant ListF32 HL134290 / HL / NHLBI NIH HHS / United States
R01 NS041588 / NS / NINDS NIH HHS / United States
U01 NS041588 / NS / NINDS NIH HHS / United States