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Fine particulate air pollution and premature atrial contractions: The REasons for Geographic And Racial Differences in Stroke study.

TitleFine particulate air pollution and premature atrial contractions: The REasons for Geographic And Racial Differences in Stroke study.
Publication TypeJournal Article
Year of Publication2017
AuthorsO'Neal, WT, Soliman, EZ, Efird, JT, Judd, SE, Howard, VJ, Howard, G, McClure, LA
JournalJ Expo Sci Environ Epidemiol
Volume27
Issue3
Pagination271-275
Date Published2017 05
ISSN1559-064X
KeywordsAfrican Americans, Aged, Aged, 80 and over, Air Pollutants, Air Pollution, Atrial Premature Complexes, Ethnic Groups, Female, Geographic Information Systems, Geography, Humans, Interviews as Topic, Male, Middle Aged, Multivariate Analysis, Particle Size, Particulate Matter, Prospective Studies, Risk Factors, Southeastern United States, Stroke
Abstract

Several reports have suggested that particulate matter (PM) exposure increases the risk for atrial arrhythmias. However, data from large-scale epidemiologic studies supporting this hypothesis are lacking. We examined the association of PM <2.5 μm in diameter (PM) concentration with premature atrial contractions (PACs) in 26,609 (mean age=65±9.4 years; 55% female; 41% black) participants from the REGARDS (REasons for Geographic And Racial Differences in Stroke) study. Estimates of short- (2 weeks) and long-term (1 year) PM exposure were computed before each participant's baseline visit using geographic information system data on the individual level at the coordinates of study participants' residences. PACs were identified from baseline electrocardiograms. A total of 2140 (8.2%) participants had evidence of PACs on the baseline electrocardiogram. Short-term PM (per 10 μg/m) exposure was not associated with PACs (OR=1.09, 95% CI=0.98, 1.23). Increases in long-term PM (per 10 μg/m) were associated with PACs (OR=1.40, 95% CI=1.10, 1.78). Interactions were not detected for short- and long-term PM exposure by age, sex, or race. Long- but not short-term PM exposure is associated with PACs. This suggests a role for long-term PM exposure in initiating supraventricular arrhythmias that are triggered by PACs.

DOI10.1038/jes.2016.46
Alternate JournalJ Expo Sci Environ Epidemiol
PubMed ID27649843
PubMed Central IDPMC5457811
Grant ListF32 HL134290 / HL / NHLBI NIH HHS / United States
R01 NS041588 / NS / NINDS NIH HHS / United States
U01 NS041588 / NS / NINDS NIH HHS / United States